Project information
STRUCTURAL BIOLOGY – NEXT GENERATION: from isolated molecules to cells, from cells to tissues.

Information

This project doesn't include Faculty of Science. It includes Central European Institute of Technology. Official project website can be found on muni.cz.

Project Identification

GX19-26041X (kod CEP: GX19-26041X)

Project Period

1/2019 - 12/2023

Investor / Pogramme / Project type

Czech Science Foundation

EXPRO

MU Faculty or unit

Central European Institute of Technology

doc. Mgr. Lukáš Trantírek, Ph.D.

STRUCTURAL BIOLOGY – NEXT GENERATION: from isolated molecules to cells, from cells to tissues.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Publications

Total number of publications: 9

2025

Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

RYNEŠ Jan IŠTVÁNKOVÁ Eva KRAFČÍKOVÁ Michaela LUCHINAT Enrico BARBIERI Letizia BANCI Lucia KAMARÝTOVÁ Kristýna LOJA Tomáš FAFÍLEK Bohumil RICO LLANOS Gustavo KREJČÍ Pavel MACUREK Libor TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš

Article in Periodical

Communications Biology, year: 2025, volume: 8, edition: 1, DOI

2024

A sodium/potassium switch for G4-prone G/C-rich sequences

LUO Yu LENARČIČ ŽIVKOVIC Martina WANG Jiawei RYNEŠ Jan TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš VERGA Daniela MERGNY Jean-Louis

Article in Periodical

Nucleic acids research, year: 2024, volume: 52, edition: 1, DOI
In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells

VÍŠKOVÁ Pavlína IŠTVÁNKOVÁ Eva RYNEŠ Jan DŽATKO Šimon LOJA Tomáš LENARČIČ ŽIVKOVIC Martina RIGO Riccardo EL-KHOURY Roberto SERRANO-CHACON Israel DAMHA Masad J GONZALEZ Carlos MERGNY Jean-Louis TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš

Article in Periodical

Nature Communications, year: 2024, volume: 15, edition: 1, DOI

2023

DNA i-motif formation at neutral pH is driven by kinetic partitioning

ŠKOLÁKOVÁ Petra GAJARSKÝ Martin PALACKÝ Jan ŠUBERT Denis RENČIUK Daniel TRANTÍREK Lukáš MERGNY Jean-Louis VORLICKOVA Michaela

Article in Periodical

Nucleic Acids Research, year: 2023, volume: 51, edition: 6, DOI

2021

In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells

BROFT P. DŽATKO Šimon KRAFČÍKOVÁ Michaela WACKER A. HANSEL-HERTSCH Robert DOTSCH Volker TRANTÍREK Lukáš SCHWALBE Harald

Article in Periodical

Angewandte Chemie International Edition, year: 2021, volume: 60, edition: 2, DOI
Insight into formation propensity of pseudocircular DNA G-hairpins

LENARČIČ ŽIVKOVIĆ Martina GAJARSKÝ Martin BEKOVÁ Kateřina STADLBAUER P. VICHEREK Lukáš PETROVA M. FIALA Radovan ROSENBERG I. ŠPONER Jiří PLAVEC J. TRANTÍREK Lukáš

Article in Periodical

Nucleic acids research, year: 2021, volume: 49, edition: 4, DOI
Thermal and pH stabilities of i‐DNA: confronting in vitro experiments with models and in‐cell NMR data

CHENG Mingpan QIU Dehui TAMON Liezel IŠTVÁNKOVÁ Eva VÍŠKOVÁ Pavlína AMRANE Samir GUÉDIN Aurore CHEN Jielin LACROIX Laurent JU Huangxian TRANTÍREK Lukáš SAHAKYAN Aleksandr B. ZHOU Jun MERGNY Jean-Louis

Article in Periodical

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, year: 2021, volume: 60, edition: 18, DOI

2019

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

HARNOŠ Jakub CANIZAL M.C.A. JURÁSEK Miroslav KUMAR Jitender HOLLER Cornelia SCHAMBONY Alexandra HANÁKOVÁ Kateřina BERNATÍK Ondřej ZDRÁHAL Zbyněk GÖMÖRYOVÁ Kristína GYBEĽ Tomáš RADASZKIEWICZ Tomasz Witold KRAVEC Marek TRANTÍREK Lukáš RYNEŠ Jan DAVE Zankruti FERNANDEZ-LLAMAZARES Ana Iris VÁCHA Robert TRIPSIANES Konstantinos HOFFMANN Carsten BRYJA Vítězslav

Article in Periodical

Nature Communications, year: 2019, volume: 10, edition: APR 18 2019, DOI
Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy

KRAFČÍKOVÁ Michaela DŽATKO Šimon CARON C. GRANZHAN A. FIALA Radovan LOJA Tomáš TEULADE-FICHOU M.P. FESSL T. HANSEL-HERTSCH R. MERGNY J.L. FOLDYNOVA-TRANTIRKOVA S. TRANTÍREK Lukáš

Article in Periodical

Journal of the American Chemical Society, year: 2019, volume: 141, edition: 34, DOI